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Pazartesi-Cuma 15:30-18:30

21 Ara 2020

Hepatocellular carcinoma (HCC) is the fifth most common
cancer amongman and seventh among woman and ranked as
the third most common cause of cancer-related deaths [1, 2].
Chronic liver injury, Hepatitis B (HBV) and C (HCV) virus
infections, alcohol-associated diseases, and aflatoxin intoxications
are the leading causes of HCC development. Several
mutations affecting WNT/𝛽-Catenin, PI3K/RAS, and oxidative
stress signaling pathways as well as hot spotmutations in
TP53 were frequently observed in hepatocarcinogenesis [3].
Orthotopic liver transplantation (OLT) is the most effective
treatment option for patients with early diagnosis, albeit not
suitable for advanced cases [4]. Despite the approval of two
tyrosine kinase inhibitors, namely, sorafenib and regorafenib,
for advanced cases, 5-year survival of HCC patients is only
less than 20% [1]. … Read More